Acne Cure News

Minocycline gel shows advantage over oral minocycline in treating acne

November 11, 2016. Healio Dermatology News.

BioPharmX presented results of two studies comparing oral and topical minocycline gel during a poster session at the Skin Disease Education Foundation’s 17th annual Las Vegas Dermatology Seminar. In the first study, daily application of BPX-01 1% topical minocycline gel in 4 weeks was well-tolerated, with patients showing significant reduction in P. acnes bacteria with no detectable minocycline in the plasma, according to a press release from BioPharmX.

A reduction in P. acnes counts without evidence of systemic exposure confirmed prior observations confirmed prior study results that indicated that BPX-01 was effectively delivered into the pilosebaceous units, according to the release. In a second study, daily administration of oral minocycline produced results of high circulating levels of minocycline, according to the release. “These two studies suggest that BPX-01 topical minocycline may have a favorable pharmacokinetic advantage over oral minocycline for the treatment of acne vulgaris,” the press release reported. BioPharmX reports it is conducting a confirmatory phase 2b study to support the results.


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