Our understanding of the microbiome and the role of P. acnes in skin homeostasis and acne pathogenesis is evolving. Multiple methods for sampling and identifying the skin's microbiome exist and understanding the differences between the abilities of various methods to characterize the microbial landscape is warranted. This study compared the microbial diversity of samples obtained from the cheeks of twenty volunteers, collected by surface swab, pore strips, and cyanoacrylate glue follicular biopsy.
Phenotype and antimicrobial activity of Th17 cells induced by Propionibacterium acnes strains associated with healthy and acne skin
Studies have emphasized the importance of disease-associated microorganisms in perturbed communities, however, the protective roles of commensals are largely under recognized and poorly understood. Using acne as a model disease, we investigated the determinants of the overall virulence property of the skin microbiota when disease- and health-associated organisms coexist in the community.
A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes
Acne dysbiosis happens when there is a microbial imbalance of the over-growth of Propionibacterium acnes (P. acnes) in the acne microbiome. In our previous study, we demonstrated that Staphylococcus epidermidis (S. epidermidis, a probiotic skin bacterium) can exploit glycerol fermentation to produce short-chain fatty acids (SCFAs) which have antimicrobial activities to suppress the growth of P. acnes.
Sometimes, seeing the big picture means drilling down to consider the smallest components that comprise the overall canvas. This is clearly true when considering the skin and when considering the microbiomes that cooperate to paint the larger picture.
In recent years, there have been an increasing number of skincare products entering the market touting probiotics. In this review we will look at the science supporting the use of topical probiotics in an effort to answer the question “are they worth the hype?”
Topical dapsone gel is a sulfone antibiotic approved for acne treatment. No microbiology studies were conducted during dapsone gel clinical trials and it is unclear whether 1) dapsone has antimicrobial activity that may be of clinical relevance in dermatology and 2) dapsone could affect the normal microbiome of facial skin where it is most commonly applied. This study assessed the in vitro activity of dapsone versus Gram-positive and Gram-negative bacterial pathogens obtained from patients with infections.
Xycrobe Therapeutics announced it has entered into a research agreement with Johnson & Johnson Consumer focusing on application of Xycrobe’s technology for the treatment of inflammatory skin diseases.
Despite regular washing and contact with bacteria-laden objects, our personal milieu of skin microbes remains highly stable over time, reports a metagenomics study. The authors say this knowledge could be applied to better understand a wide range of human skin disorders through the development of prebiotic, probiotic, and microbial transplantation approaches.
Recognizing that the microbiome is part of the human immune system will advance treatment of both cancer and infections
We propose that it is time to rethink the components of human immunity and recognize that some microbes that reside within the skin are necessary to maintain immune homeostasis. These microbial cells should therefore be considered not as foreign organisms that can cause infections, but an essential part of ourselves.