Acne Cure News

Phenotype Archives

Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?

Inflammatory bowel disease (IBD) may develop due to an inflammatory response to commensal gut microbiota triggered by environmental factors in a genetically susceptible host. Isotretinoin (acne therapy) has been inconsistently associated with IBD onset and flares but prior treatment with antibiotics, also associated with IBD development, complicates the confirmation of this association.

High Copy Numbers of β-Defensin Cluster on 8p23.1, Confer Genetic Susceptibility, and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa

Hidradenitis suppurativa/acne inversa (HS) has a multifactorial pathogenesis, with many patients reporting positive family history. Nine β-defensin genes (among them DEFB4 and DEFB103, encoding for proinflammatory mediators human β-defensin-2 and human β-defensin-3, respectively) exist as a cluster (DEFB) affected by copy number (CN). We hypothesized that CNs are greater in patients with HS and that they are linked to genetic susceptibility.

High Copy Numbers of Beta-Defensin Cluster on 8p23.1 Confer Genetic Susceptibility and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa

Hidradenitis suppurativa/acne inversa (HS) has multifactorial pathogenesis with many patients reporting positive family history. Nine beta-defensin genes (among them DEFB4 and DEFB103 encoding for pro-inflammatory mediators hBD-2 and hBD-3, respectively) exist as a cluster (DEFB) affected by copy number variations (CNs).

Expanding the spectrum of γ-secretase gene mutation-associated phenotypes: two novel mutations segregating with familial Hidradenitis suppurativa (Acne inversa) and Acne conglobata

Hidradenitis suppurativa (HS) and Acne conglobate (AC) are well-described chronic inflammatory diseases of cutaneous follicular occlusion. HS is characterized by painful comedo-like lesions in the apocrine sweat or sebaceous glands, while AC is characterized by interconnecting abscesses on the trunk, buttocks, upper arms, thighs and face.