A comprehensive overview of the acne exposome
Efficacy and safety of a 12-month treatment with a combination of hydroxypinacolone retinoate and retinol glycospheres as maintenance therapy in acne patients after oral isotretinoin
A correct therapeutic management of acne should include a maintenance therapy to prevent recurrences after discontinuing a successful treatment. The aim of this study is to investigate efficacy and safety of a 12-month maintenance treatment with a product, based on Retinsphere technology that combines retinol encapsulated in glycospheres and hydroxypinacolone retinoate (Biretix gel®), to control acne relapse after a treatment with oral isotretinoin (O.I.).
Safety and efficacy of fixed-dose 10 mg daily isotretinoin treatment for acne vulgaris in Malaysia. Yap FB
Low-dose isotretinoin is used to reduce side effects albeit higher relapse. This study aimed to determine the efficacy and safety of fixed-dose 10 mg daily isotretinoin for the treatment of acne.
In a relapse study, researchers report successful initial treatment with once-daily ivermectin 1% cream (Soolantra, Galderma) resulted in longer remission among patients with moderate-to-severe papulopustular rosacea, compared with initial treatment with twice daily metronidazole 0.75% cream. Papulopustular rosacea remission is known to be challenging to maintain post treatment. Patients in the two groups studied were successfully treated for 16 weeks with either Ivermectin 1% cream or metronidazole 0.75% cream.
Clinical studies in dermatology require a post-treatment observation phase to define the impact of the intervention on the natural history of the complaint
The use of a post-treatment period of observation or "regression phase" is common in pharmaceutical and cosmetic clinical dermatology studies. Regression phases can be incorporated into a variety of study designs, ranging from simple post-treatment observation for a defined period, as has been used for moisturizers, antidandruff formulations, and treatments for acne, to more complex randomized intermittent-treatment designs, as used in studies of psoriasis pharmacotherapies. Extensive information can be derived from a regression phase.
Acne in adult women is a frequent hard-to-manage disease with many relapse cases. It mostly interferes with the quality of life of patients, bringing them major metabolic and social losses. As androgenic hormones play a very important role in the acne pathogenesis, the early diagnosis of hyperandrogenic states is very useful for the proper evaluation of each patient and for a better choice of therapeutic management.
This letter to the Editor illustrates studies that have demonstrated the efficacy of isotretinoin in the treatment of nodulocystic acne, although ideal dosing is unclear.
The importance of the cumulative dose of isotretinoin with respect to relapse of acne vulgaris remains controversial. Although guidelines recommend 0.5-1.0 mg/kg/d to a minimum cumulative dose of 120 mg/kg, there has been a trend toward the use of lower daily dosages with no reference to cumulative dose. This study aimed to determine the influence of daily and cumulative dosage on relapse in acne.
Hidradenitis suppurativa (HS): An unrecognized paradoxical effect of biologic agents (BA) used in chronic inflammatory diseases
Paradoxical hidradenitis suppurativa (HS) induced by biologic agents (BA) is scarcely reported. We sought to describe the clinical characteristics and outcome of patients developing paradoxical HS under BA.
Recent advances in the use of adapalene 0.1%/benzoyl peroxide 2.5% to treat patients with moderate to severe acne
The central role of inflammation in acne is now more clearly understood. Adapalene, a third-generation topical retinoid, down-regulates toll-like receptor 2 expression and inhibits activator protein-1 activity. In a fixed-dose combination, adapalene and benzoyl peroxide (BPO) act synergistically on inflammatory patterns through regulation of innate immunity.