A comprehensive overview of the acne exposome
Acne is the most common of all skin conditions. It affects people across several age groups, from adolescence to middle age. It is fundamentally a disorder of the pilosebaceous units of the skin, which consist of the hair follicles and the attached sebaceous glands.
In this issue of Experimental Dermatology, Dr. Melnik presents the hypothesis that acne is caused by inappropriate survival of cells in the sebaceous duct and gland.
Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study
Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. Safety and efficacy of OG 7.5% gel were evaluated in patients with moderate to severe facial acne vulgaris.
Targeting of sebaceous glands to treat acne by micro-insulated needles with radio frequency in a rabbit ear model
Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro-insulated needle RF applicator has not yet been studied in an animal model. The purpose of this study was to evaluate the effectiveness of a micro-insulated needle RF applicator in a rabbit ear acne (REA) model.
In recent years, there have been an increasing number of skincare products entering the market touting probiotics. In this review we will look at the science supporting the use of topical probiotics in an effort to answer the question “are they worth the hype?”
Significant reduction of inflammation and sebaceous glands size in acne vulgaris lesions after intense pulsed light treatment
Intense pulsed light (IPL) has been used for years in treatment of acne vulgaris. However, quantitative evaluation of histopathological changes after its use as a sole therapy was poorly investigated.
Laser- and light-based treatments for acne have a long history of use and address the desire for interventions that can overcome the problems of poor patient compliance with topical therapies and side effects accompanying systemic medications.
A switch from cell-mediated to humoral immunity (helper T 1 [Th1] to helper T 2 [Th2] shift) during gestation plays a key role in placental immune tolerance. As a result, skin diseases that are Th2 mediated often worsen, whereas skin diseases that are Th1 mediated often improve during gestation.
Lasers represent an extremely attractive option for acne patients who have not responded to traditional therapies and for those who either cannot take or who do not want to take oral medications including antibiotics or isotretinoin.